Thailanstatin A CAS 1426953-21-0

Product Description:

Product Name: Thailanstatin A CAS NO: 1426953-21-0

 

Synonyms:

(3R,5S,7R,8R)-7-{(1E,3E)-5-(2S,3S,5R,6R)-5-{(2Z,4S)-4-(acetyloxy)pent-2-enoylamino}-3,6-dimethyltetrahydro-2H-pyran-2-yl-3-methylpenta-1,3-dien-1-yl}-8-hydroxy-1,6-dioxaspiro2.5oct-5-ylacetic acid;

1,6-Dioxaspiro2.5octane-5-aceticacid,7-(1E,3E)-5-(2S,3S,5R,6R)-5-(2Z,4S)-4-(acetyloxy)-1-oxo-2-penten-1-ylaminotetrahydro-3,6-dimethyl-2H-pyran-2-yl-3-methyl-1,3-pentadien-1-yl-8-hydroxy-, (3R,5S,7R,8R)-;

 

Chemical Physical Properties:

Appearance: Solid powder

Assay : Greater than or equal to 99.0 percent

 

Thailanstatin A, a promising lead compound for drug discovery and development efforts, is derived from Thailandensis burkholderia MSMB43. It reveals low nanomolar to subnanomolar cytotoxicity against a variety of human cancer cell lines.

Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC50=650 nM). Thailanstatin A exerts effects via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome and shows low-nM to sub-nM IC50s against multiple cancer cell lines. Thailanstatin A, a payload for ADCs, is conjugated to the lysines on trastuzumab yielding "linker-less" ADC.

 

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